A number of genomes have been completely sequenced and the list is increasing everyday. Comparative analysis of these fully sequenced genomes, particularly closely related organisms, is likely to help in establishing sequence-phenotype relationships. A number of molecular processes contribute to genomic diversity such as, insertion and deletion, single nucleotide variations (SNV), duplication, repeat expansion and recombination. All these can contribute to phenotypic divergence depending on the situation. Therefore it is important to identify all the changes that are present between any two genomes for detailed biological studies. ABWGAT offers a simple one step solution for comparing any two fully sequenced genomes. The output is in the form of parsed data listing all the variations and using the coordinates of one of the genomes (S or reference genome) for reporting. The analysis can be carried out by selecting any of the genome in a pair as a reference genome or one can upload custom genome sequences. The tool has the ability to analyse custom genome sequences provided the uploaded sequence is either close to one of the genome sequences available in the drop down menu or close to another uploaded sequence. New organisms will be added to the menu time to time as their sequences become available in future. Time taken for analysis may vary depending on the size of the genomes and number of sequences in the queue. The system has capability to run a few jobs simultaneously. If you do not get results within 6 hours please contact us. We will also like to get your feedback for future improvement.

When submit your query, you will get a job identification number. Please note down this number to retrieve result at a later time. Also note that result may not be immediately available as a number of job may be in the queue. Please see the following citation for details of the algorithm.

Comparative analysis of bacterial genomes:identification of divergent regions in mycobacterial strains using an anchor-based approach.
Anchal Vishnoi, Rahul Roy and Alok Bhattacharya. Nucleic Acids Research.